A 43-YEAR-OLD Mildura woman is dead following a fatal collision overnight.

Major Collision Investigation Unit detectives are investigating the incident after the woman  was struck by a vehicle as she attempted to cross San Mateo Avenue near the intersection of Kalimna Drive.

The incident is believed to have occurred just before 11pm.

The driver of the vehicle, a Mildura woman, allegedly left the scene, but returned shortly after.

Paramedics and CFA treated the 43-year-old, however she died shortly afterwards.

Investigators will speak to the driver and another person later this morning to establish the exact circumstances surrounding the collision.

Police are appealing for anyone with information regarding the incident to contact Crime Stoppers on 1800 333 000, or submit a confidential crime report online at www.crimestoppersvic.com.au